Wolfenstein: Youngblood é uma nova experiência cooperativa da MachineGames, o estúdio premiado que desenvolveu o aclamado Wolfenstein II: The New Colossus. Ambientado em 1980, 19 anos depois que BJ Blazkowicz iniciou a segunda Revolução Americana, Wolfenstein: Youngblood apresenta a próxima geração Blazkowicz à luta contra os nazistas. Jogue como uma das filhas gêmeas de BJ, Jess e Soph, enquanto procura seu pai desaparecido na Paris ocupada pelos nazistas.

A spin-off in the alternate-history Wolfenstein series, Youngblood is set in 1980, nineteen years after the liberation of America from Nazi rule. Though the United States has been freed, the fragile global coalition has crumbled, leaving much of Europe still under the Nazi boot. The legendary resistance hero B. J. Blazkowicz has settled into a quieter life raising his twin teenage daughters, Jessie and Zofia, training them to fight and survive. When Blazkowicz suddenly vanishes without a trace, the sisters discover clues in a hidden attic room pointing to Nazi-occupied Paris, where he had gone to make contact with the French Resistance. Determined to find their father and convinced the authorities will not pursue him, Jessie and Zofia commandeer a helicopter and a pair of powered armor suits and set off for France. There, amid a city under brutal occupation, the young Blazkowicz sisters take up the family fight, joining the Resistance and beginning to unravel a sinister Nazi conspiracy.