James Bond 007: Blood Stone features the likeness and voice talent of Daniel Craig, Joss Stone and Judi Dench and features an epic, original story developed by legendary screenwriter Bruce Feirstein. Players can engage in cover-based firefights, lethal hand-to-hand combat and speed their way through explosive adrenaline-fueled driving sequences as they embark on a global chase leading to action on land and sea through Athens, Istanbul, Monaco and Bangkok. Gamers can also feel what it is like to be a 00 agent, as they take the battle online in several robust 16-person multi-player modes that require skill, teamwork and strategy as players compete in matches that will have spies battling mercenaries.

When MI6 uncovers a plot by the international terrorist Greco to carry out a devastating suicide attack on the G-20 leaders gathered for a summit in Athens, M assigns her top agent, James Bond, to stop him. Bond persegue Greco pela cidade e, em uma perseguição em alta velocidade ao volante de um Aston Martin, frustra o plano mortal antes que ele possa chegar ao cume. Mas a missão é apenas o começo. The following morning, M sends Bond to Istanbul on the trail of Malcolm Tedworth, a Ministry of Defence researcher who vanished while conducting top-secret work and is believed to have been kidnapped for it. As Bond races to recover the missing scientist and his research, the investigation draws him ever deeper into a dangerous international conspiracy spanning the globe.