Wolfenstein II: The New Colossus is the eleventh installment of the Wolfenstein series and a sequel to the 2014's Wolfenstein: The New Order. The game follows the main protagonist, William Joseph "B.J." Blazkowicz, in his efforts to ignite a Second American Revolution. The game is played from a first-person perspective and most of its levels are navigated on foot. The story is arranged in chapters, which players complete in order to progress. A binary choice in the prologue alters the game's entire storyline; some characters and small plot points are replaced throughout the timelines. The game features a variety of weapons, most of which can be dual wielded. A cover system is also present.

After the events of the first game, in which General Wilhelm "Deathshead" Strasse is eliminated, the Kreisau Circle retrieves the critically injured William "B. J. " Blazkowicz from Deathshead's fortress before destroying it with a nuclear cannon. He. is still recovering from his wounds on a stolen U-boat called Eva’s Hammer. Suddenly, the U-boat is attacked by Frau Engel, a sadistic Nazi commander and captures Caroline. Blazkowicz devises a plan to get himself captured and taken to Engel's airship, the Ausmerzer, which is suspending the U-boat above water. Engel tries to get her daughter Sigrun to decapitate Caroline, but the former refuses, resulting in Engel killing Caroline herself. Sigrun has a change of heart and tackles Engel, allowing Blazkowicz to use Caroline's armor. Blazkowicz disconnects Eva's Hammer from the Ausmerzer and flees back to the U-boat with Caroline's body. Now armed with Caroline's armor, B.J is ready to return stateside, avenge his friends, kill every Nazi in sight and spark the second American Revolution.