Six monsters battle through seven destructive locations in an attempt to prove themselves as the greatest monster to walk the Earth. Each monster has a personal set of punches, kicks and special moves to Dominate over the competition. Game features include 7 monsters each with their own home arena and special moves, power-ups and weapons revealed by destroyings buildings, five different modes including link mode to play against four friends, and customized fights for unlimited styles of gameplay.

Meteor X appears over Tokyo 2 and starts projecting magnetic waves which causes neurological damage to several monsters, causing them to go berserk. The monsters begin to attack Earth and its neighboring planets (led by Mecha-King Ghidorah), however, one monster remains unaffected by the waves and it's up to it to stop the others and destroy Meteor X.