Moonlight Syndrome is a horror-themed adventure game developed and published by Human Entertainment for the PlayStation in October 1997. An entry in the company's Twilight Syndrome series, the game was directed and co-written by Goichi Suda.

A teenage girl named Mika meets a mysterious person on her way home, who warns her of horrifying events that are about to happen to her and her friends. More strange events are happening this evening: a cancelled meeting, a boy who seems to have followed her - but the next day, she almost forgets it... until she hears on the news that her schoolmate Kyoko was killed in a truck accident. Now Mika must find out what is truly happening around her. And so does Ryo, Kyoko's brother, who has been seeing strange dreams lately...