The follow up to Danganronpa: Trigger Happy Havoc. The main character, Hajime Hinata, a new 'Ultimate' student at Hope's Peak Academy. On their first day, Hajime and all of his classmates are taken on a field trip to the mysterious Jabberwock island by their anthropomorphic rabbit teacher, Usami. Usami explains that on this island the students are to have fun together and become friends to gather Hope Fragments. Usami's field trip does not go as planned when Monokuma appears and begins a new Killing Game. Anyone that wants to leave the island must commit a murder and get away with it. If the murderer is successful, he/she is allowed to leave the island, while everyone else is killed. When a murder occurs, the player investigates. After the investigations, a trial commences to determine who the culprit is.

Danganronpa 2: Goodbye Despair strands a class of elite "Ultimate" high-school students on the sunny, seemingly idyllic Jabberwock Island for what is billed as a school field trip. The peace shatters when a menacing robotic bear named Monokuma seizes control and traps everyone in a twisted killing game: the only way off the island is to murder a fellow student and escape blame. Players take the role of Hajime Hinata, who must survive each grisly incident by investigating the crime scenes for clues. In tense class trials, the surviving students debate the evidence to expose the culprit, knowing that a wrong verdict will doom them all.